Active Ingredient: Isoprenaline
Serious episodes of Adams-Stokes attacks (except when caused by ventricular tachycardia of fibrillation).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intracardiac, 0.02 milligrams isoprenaline, one dose.
For:
Subcutaneous, 0.2 milligrams isoprenaline, one dose. Afterwards, subcutaneous, between 0.15 milligrams isoprenaline and 0.2 milligrams isoprenaline,.
Initial dose: 0.2 mg.
Subsequent administration dose range: 0.15 mg to 0.2 mg.
Subsequent dosage and method of administration depend on the ventricular rate and the rapidity with which the cardiac pacemaker can take over when the medicine is gradually withdrawn.
Isoprenaline should generally be started at the lowest recommended dose and the rate of administration gradually increased if necessary while carefully monitoring the patient.
Elderly patients may be more sensitive to the effects of sympathomimetics and lower doses may be required.
For:
Intramuscular, 0.2 milligrams isoprenaline, one dose. Afterwards, intramuscular, between 0.02 milligrams isoprenaline and 1 milligrams isoprenaline, one dose.
Initial dose: 0.2 mg.
Subsequent administration dose range: 0.02 mg to 1 mg.
Subsequent dosage and method of administration depend on the ventricular rate and the rapidity with which the cardiac pacemaker can take over when the medicine is gradually withdrawn.
Isoprenaline should generally be started at the lowest recommended dose and the rate of administration gradually increased if necessary while carefully monitoring the patient.
Elderly patients may be more sensitive to the effects of sympathomimetics and lower doses may be required.
For:
Regimen A: Intravenous, between 0.02 milligrams isoprenaline and 0.06 milligrams isoprenaline, one dose. Afterwards, intravenous, between 0.01 milligrams isoprenaline and 0.2 milligrams isoprenaline,.
Regimen B: Intravenous, 5 micrograms isoprenaline, once every minute.
| Route of Administration | Initial dose | Subsequent administration dose range* |
|---|---|---|
| Bolus intravenous injection | 0.02 mg to 0.06 mg | 0.01 mg to 0.2 mg |
| Intravenous infusion | 5 mcg/min |
* Subsequent dosage and method of administration depend on the ventricular rate and the rapidity with which the cardiac pacemaker can take over when the medicine is gradually withdrawn.
Isoprenaline should generally be started at the lowest recommended dose and the rate of administration gradually increased if necessary while carefully monitoring the patient.
Elderly patients may be more sensitive to the effects of sympathomimetics and lower doses may be required.
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