Active Ingredient: Quinapril
For the treatment of congestive heart failure when given concomitantly with a diuretic and/or cardiac glycoside. Treatment of congestive heart failure with quinapril should always be initiated under close medical supervision.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
2.5 - 40 mg
From 2.5 To 40 mg once every day
In order to closely monitor patients for symptomatic hypotension, a single 2.5 mg initial dosage is recommended. After this, patients should be titrated to an effective dose: (up to 40 mg/day) given in 1 or 2 doses with concomitant diuretic and/or cardiac glycoside therapy. Patients are usually maintained effectively on doses of 10 mg/day to 20 mg/day given with concomitant therapy. Take either with or without food. The dose should always be taken at about the same time of day to help increase compliance.
In the treatment of severe or unstable congestive heart failure, quinapril should always be initiated in hospital under close medical supervision.
Other patients who may also be considered to be at higher risk and should have treatment initiated in hospital include: patients who are on high dose loop diuretics (e.g. >80 mg furosemide) or on multiple diuretic therapy, have hypovolemia, hyponatremia (serum sodium <130 mgEq/l) or systolic blood pressure <90 mmHg, are on high dose vasodilator therapy, have a serum creatinine >150 µmol/l or are aged 70 years or over.
In elderly patients and in patients with a creatinine clearance of less than 40 mL/min, an initial dosage in essential hypertension of 2.5 mg is recommended followed by titration to the optimal response.
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