Active Ingredient: Dupilumab
Dupilumab is indicated for the treatment of moderate-to-severe atopic dermatitis in adults and adolescents 12 years and older who are candidates for systemic therapy.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
300 - 600 mg
From 300 To 600 mg once every 14 day(s)
600 mg
300 mg
The recommended dose of dupilumab for adult patients is an initial dose of 600 mg, followed by 300 mg given every other week administered as subcutaneous injection.
Dupilumab can be used with or without topical corticosteroids. Topical calcineurin inhibitors may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas.
Consideration should be given to discontinuing treatment in patients who have shown no response after 16 weeks of treatment for atopic dermatitis. Some patients with initial partial response may subsequently improve with continued treatment beyond 16 weeks. If dupilumab treatment interruption becomes necessary, patients can still be successfully re-treated.
If a dose is missed, administer the dose as soon as possible. Thereafter, resume dosing at the regular scheduled time.
Dupilumab is administered by subcutaneous injection into the thigh or abdomen, except for the 5 cm around the navel.
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