Active Ingredient: Bevacizumab
Bevacizumab, in combination with topotecan, or pegylated liposomal doxorubicin is indicated for the treatment of adult patients with platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who received no more than two prior chemotherapy regimens and who have not received prior therapy with bevacizumab or other VEGF inhibitors or VEGF receptor-targeted agents.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, 10 milligrams bevacizumab, once every 2 weeks.
Regimen B: Intravenous, 15 milligrams bevacizumab, once every 3 weeks.
Bevacizumab is administered in combination with one of the following agents – topotecan (given weekly) or pegylated liposomal doxorubicin.
The recommended dose of bevacizumab is 10 mg/kg of body weight given once every 2 weeks as an intravenous infusion.
When bevacizumab is administered in combination with topotecan (given on days 1-5, every 3 weeks), the recommended dose of bevacizumab is 15 mg/kg of body weight given once every 3 weeks as an intravenous infusion.
It is recommended that treatment be continued until disease progression or unacceptable toxicity.
It should not be administered as an intravenous push or bolus.
Dose reduction for adverse reactions is not recommended. If indicated, therapy should either be permanently discontinued or temporarily suspended.
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