Active Ingredient: Zofenopril
Zofenopril is indicated for the treatment of mild to moderate essential hypertension.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
7.5 - 60 mg
From 7.5 To 60 mg once every day
15 mg
The need for dosage titration should be determined by measurement of blood pressure just before the next dose. The dose should be increased at an interval of four weeks.
Treatment should be started with 15mg once daily and titrated upwards to achieve optimal blood pressure control.
The usual effective dose is 30mg once daily. The maximum dose is 60mg per day administered in a single or two divided doses. In case of inadequate response, other antihypertensive agents such as diuretics may be added.
First-dose hypotension may occur in high risk patients. Initiation of therapy with ACE inhibitors requires correction of salt and/or volume deficiencies, discontinuation of an existing diuretic therapy for two to three days before ACE inhibition and a starting dose of 15mg daily. If this is not possible, the initial dose should be 7.5 mg daily.
Patients at high risk for severe acute hypotension should be monitored closely preferably in hospital, for as long as the maximal effect is expected after administration of the first dose and whenever the dose of ACE inhibitor and/or diuretic is increased. This also applies to patients with angina pectoris or cerebrovascular disease in whom excessive hypotension could result in a myocardial infarction or cerebrovascular accident.
Zofenopril can be taken before, during or after meals.
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