Lambert-Eaton myasthenic syndrome (LEMS)

Active Ingredient: Amifampridine

Indication for Amifampridine

Population group: only adults (18 years old or older)
Therapeutic intent: Palliative intent

Symptomatic treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults.

For this indication, competent medicine agencies globally authorize below treatments:

15-60 mg in 3 divided doses daily

Route of admnistration

Oral

Defined daily dose

15 - 60 mg

Dosage regimen

From 5 To 20 mg 3 time(s) per day every day

Loading dose

15 mg

Detailed description

Amifampridine should be given in divided doses, three or four times a day. The recommended starting dose is 15 mg amifampridine a day, which can be increased in 5 mg increments every 4 to 5 days, to a maximum of 60 mg per day. No single dose should exceed 20 mg.

Dosage considerations

Tablets are to be taken with food.

Active ingredient

Amifampridine

Amifampridine blocks voltage-dependent potassium channels, thereby prolonging pre-synaptic cell membrane depolarisation. Prolonging the action potential enhances the transport of calcium into the nerve ending. The resulting increase in intra-cellular calcium concentrations facilitates exocytosis of acetylcholine-containing vesicles, which in turn enhances neuromuscular transmission.

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