Active Ingredient: Crizotinib
Crizotinib as monotherapy is indicated for the treatment of adults with previously treated anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 250 milligrams crizotinib, 2 times daily.
The recommended dose schedule of crizotinib is 250 mg twice daily (500 mg daily) taken continuously.
If a dose is missed, then it should be taken as soon as the patient remembers unless it is less than 6 hours until the next dose, in which case the patient should not take the missed dose. Patients should not take 2 doses at the same time to make up for a missed dose.
It may be taken either after a meal or while fasted.
Grapefruit or grapefruit juice should be avoided since it may increase crizotinib plasma concentration. St. John’s wort should be avoided since it may decrease crizotinib plasma concentration.
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