Active Ingredient: Gabapentin
Gabapentin is indicated for the treatment of peripheral neuropathic pain such as painful diabetic neuropathy and postherpetic neuralgia in adults.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
900 - 3,600 mg
From 300 To 1,200 mg 3 time(s) per day every day
The therapy may be initiated by titrating the dose as described in Table 1. Alternatively, the starting dose is 900 mg/day given as three equally divided doses.
Dosing chart – Initial titration:
| Day 1 | Day 2 | Day 3 |
|---|---|---|
| 300 mg once a day | 300 mg two times a day | 300 mg three times a day |
Thereafter, based on individual patient response and tolerability, the dose can be further increased in 300 mg/day increments every 2-3 days up to a maximum dose of 3600 mg/day. Slower titration of gabapentin dosage may be appropriate for individual patients. The minimum time to reach a dose of 1800 mg/day is one week, to reach 2400 mg/day is a total of 2 weeks, and to reach 3600 mg/day is a total of 3 weeks.
In the treatment of peripheral neuropathic pain such as painful diabetic neuropathy and post-herpetic neuralgia, efficacy and safety have not been examined in clinical studies for treatment periods longer than 5 months. If a patient requires dosing longer than 5 months for the treatment of peripheral neuropathic pain, the treating physician should assess the patient’s clinical status and determine the need for additional therapy.
Elderly patients may require dosage adjustment because of declining renal function with age. Somnolence, peripheral oedema and asthenia may be more frequent in elderly patients.
Gabapentin can be given with or without food and should be swallowed whole with sufficient fluid-intake (e.g. a glass of water).
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