Active Ingredient: Valproic acid
Treatment of generalised, partial or other epilepsy.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
20 - 40 mg per kg of body weight
From 6.667 To 13.333 mg per kg of body weight 3 time(s) per day every day
Children over 20 kg: Initial dosage should be 400 mg/day (irrespective of weight) with spaced increases until control is achieved; this is usually within the range 20–30 mg/kg body weight per day (to the nearest whole 50 mg sachet. Where adequate control is not achieved within this range the dose may be increased to 35 mg/kg body weight per day. Above 40 mg/kg/day, clinical chemistry and haematological parameters should be monitored.
Children under 20 kg: 20 mg/kg of body weight per day (to the nearest whole 50 mg sachet); in severe cases this may be increased but only in patients in whom plasma valproic acid levels can be monitored. Above 40 mg/kg/day, clinical chemistry and haemotological parameters should be monitored.
Intravenous
20 - 40 mg per kg of body weight
From 6.667 To 13.333 mg per kg of body weight 3 time(s) per day every day
Use with children: Daily requirement for children is usually in the range 20–30 mg/kg/day and method of administration is as above. Where adequate control is not achieved within this range the dose may be increased up to 40 mg/kg/day but only in patients in whom plasma valproic acid levels can be monitored. Above 40 mg/kg/day clinical chemistry and haematological parameters should be monitored.
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