Active Ingredient: Relugolix
Relugolix is indicated for the treatment of adult patients with advanced hormone-sensitive prostate cancer.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 360 milligrams relugolix, once daily, over the duration of 1 day. Afterwards, oral, 120 milligrams relugolix, once daily.
Treatment with relugolix should be initiated with a loading dose of 360 mg (three tablets) on the first day, followed by a 120 mg (one tablet) dose taken once daily at approximately the same time each day.
Because relugolix does not induce an increase in testosterone concentrations, it is not necessary to add an anti-androgen as surge protection at initiation of therapy.
Co-administration of relugolix with oral P-glycoprotein (P-gp) inhibitors must be avoided. If co-administration is unavoidable, relugolix should be taken first and dosing should be separated by at least 6 hours. Treatment with relugolix may be interrupted for up to 2 weeks if a short course of treatment with a P-gp inhibitor is required.
Co-administration of relugolix with combined P-gp and strong cytochrome P450 (CYP) 3A inducers must be avoided. If co-administration is unavoidable, the dose of relugolix must be increased to 240 mg once daily. After discontinuation of the combined P-gp and strong CYP3A inducer, the recommended 120 mg dose of relugolix once daily must be resumed.
If a dose is missed, relugolix must be taken as soon as the patient remembers. If the dose was missed by more than 12 hours, the missed dose must not be taken and regular dosing schedule should be resumed the following day.
If treatment with relugolix is interrupted for greater than 7 days, relugolix must be restarted with a loading dose of 360 mg on the first day, followed with a dose of 120 mg once daily.
Relugolix can be taken with or without food. Relugolix tablets should be taken with some liquid as needed and should be swallowed whole.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
