Malaria

Active Ingredient: Proguanil

Indication for Proguanil

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Preventive action

Proguanil is an effective antimalarial agent. It is recommended for the prevention and suppression of malaria.

For this indication, competent medicine agencies globally authorize below treatments:

200 mg daily

For:

Dosage regimens

Oral, 200 milligrams proguanil, once daily.

Detailed description

200 mg daily.

Non-immune subjects entering a malarious area are advised to begin treatment with proguanil 1 week before, or if this is not possible, then at least 2 days before entering the malarious area. The daily dose of proguanil should be continued throughout exposure to risk and for 4 weeks after leaving the area.

Older people

There are no special dosage recommendations for the elderly, but it may be advisable to monitor elderly patients so that optimum dosage can be individually determined.

Dosage considerations

The daily dose is best taken with water, after food, at the same time each day.

25-200 mg once daily based on age

For:

Dosage regimens

Regimen A: In case that patient age in years is ≤ 1, oral, 25 milligrams proguanil, once daily.

Regimen B: In case that patient age in years is ≥ 1 and patient age in years is ≤ 4, oral, 50 milligrams proguanil, once daily.

Regimen C: In case that patient age in years is ≥ 5 and patient age in years is ≤ 8, oral, 100 milligrams proguanil, once daily.

Regimen D: In case that patient age in years is ≥ 9 and patient age in years is ≤ 14, oral, 150 milligrams proguanil, once daily.

Regimen E: In case that patient age in years is ≥ 14, oral, 200 milligrams proguanil, once daily.

Detailed description

Under 1 year: 25 mg daily.

1 to 4 years: 50 mg daily.

5 to 8 years: 100 mg daily.

9 to 14 years: 150 mg daily.

Over 14 years: 200 mg daily.

Dosage considerations

The daily dose is best taken with water, after food, at the same time each day.

Active ingredient

Proguanil

Proguanil is an antimalarial drug and dihydrofolate reductase inhibitor. It acts like the other antifolate antimalarials by interfering with the folic-folinic acid systems and thus exerts its effect mainly at the time the nucleus is dividing. Proguanil is effective against the exoerythrocytic forms of some strains of plasmodium falciparum but it has little or no activity against the exoerythrocytic forms of p. Vivax.

Read more about Proguanil

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