Resistant chronic myeloid leukemia

Active Ingredient: Hydroxycarbamide

Indication for Hydroxycarbamide

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

20-40 mg/kg body weight daily

For:

Dosage regimens

Oral, between 20 milligrams hydroxycarbamide per kilogram of body weight and 40 milligrams hydroxycarbamide per kilogram of body weight, once daily.

Detailed description

Hydroxycarbamide is used alone or in conjunction with other antitumor agents or radiation therapy to treat neoplastic diseases. Individualize treatment based on tumor type, disease state, response to treatment, patient risk factors, and current clinical practice standards.

Base all dosage on the patient’s actual or ideal weight, whichever is less.

Hydroxycarbamide is a cytotoxic drug. Follow applicable special handling and disposal procedures.

Prophylactic administration of folic acid is recommended.

Monitor blood counts at least once a week during hydroxycarbamide therapy. Severe anemia must be corrected before initiating therapy with hydroxycarbamide.

Active ingredient

Hydroxycarbamide

One of the mechanisms by which hydroxycarbamide acts is the elevation of foetal haemoglobin (HbF) concentrations in sickle cell patients. In addition hydroxycarbamide causes an immediate inhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or protein.

Read more about Hydroxycarbamide

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