Severe sepsis

Active Ingredient: Ulinastatin

Indication for Ulinastatin

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Sepsis is defined as a systemic inflammatory response syndrome (SIRS) in the presence of, or as a result of, suspected or proven infection. Severe sepsis is defined as sepsis with one of the following features: cardiovascular organ dysfunction, acute respiratory distress syndrome (ARDS), or dysfunction of two or more organs. There is a continuum of clinical manifestations from SIRS to sepsis to severe sepsis to septic shock to Multiple Organ Dysfunction Syndrome (MODS).

For this indication, competent medicine agencies globally authorize below treatments:

100,000-200,000 I.U. 1-3 times per day for 3-5 days

For:

Dosage regimens

Intravenous, between 100,000 international units ulinastatin and 200,000 international units ulinastatin, 1 to 3 times daily, over the duration of 3 to 5 days.

Detailed description

Administer 100,000 to 200,000 I.U. of ulinastatin by intravenous infusion over 1 hour each time, 1-3 times per day for 3 to 5 days. The dosage may be adjusted according to the age of patients and the severity of symptoms.

Active ingredient

Ulinastatin

Ulinastatin is a serine protease inhibitor that reduces the pro-inflammatory response as a result of sepsis, acute pancreatitis, trauma or surgery. It inhibits coagulation and fibrinolysis and promotes microperfusion. Thus, ulinastatin is an effective agent for immune modulation to prevent organ dysfunction and promote homeostasis.

Read more about Ulinastatin

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