Bronchoconstriction in patients with chronic obstructive pulmonary disease

Active Ingredient: Arformoterol

Indication for Arformoterol

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Arformoterol is indicated for the long-term, twice daily (morning and evening) maintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

For this indication, competent medicine agencies globally authorize below treatments:

15 ug twice daily

For:

Dosage regimens

Respiratory (Inhalation), 15 micrograms arformoterol, 2 times daily. The maximum allowed total dose is 30 micrograms arformoterol daily.

Detailed description

The recommended dose is one 15 mcg administered twice daily (morning and evening) by nebulization. A total daily dose of greater than 30 mcg (15 mcg twice daily) is not recommended.

If the recommended maintenance treatment regimen fails to provide the usual response, medical advice should be sought immediately, as this is often a sign of destabilization of COPD. Under these circumstances, the therapeutic regimen should be reevaluated and additional therapeutic options should be considered.

Dosage considerations

Arformoterol tartrate inhalation solution should be administered by the orally inhaled route via a standard jet nebulizer connected to an air compressor.

Active ingredient

Arformoterol

Arformoterol, the (R,R)-enantiomer of formoterol, is a selective long-acting beta2-adrenergic receptor agonist (beta2-agonist) that has two-fold greater potency than racemic formoterol (which contains both the (S,S) and (R,R)-enantiomers). The (S,S)-enantiomer is about 1,000-fold less potent as a beta2-agonist than the (R,R)-enantiomer. The pharmacologic effects of beta2-adrenoceptor agonist drugs, including arformoterol, are at least in part attributable to stimulation of intracellular adenyl cyclase.

Read more about Arformoterol

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