Active Ingredient: Rilpivirine
Rilpivirine, in combination with other antiretroviral medicinal products, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-naïve patients 12 years of age and older with a viral load ≤100,000 HIV-1 RNA copies/ml.
Genotypic resistance testing should guide the use of rilpivirine.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 25 milligrams rilpivirine, once daily to meals.
The recommended dose of rilpivirine is 25 mg taken once daily.
For patients concomitantly receiving rifabutin, the rilpivirine dose should be increased to 50 mg taken once daily. When rifabutin co-administration is stopped, the rilpivirine dose should be decreased to 25 mg once daily.
If the patient misses a dose of rilpivirine within 12 hours of the time it is usually taken, the patient must take the medicine with a meal as soon as possible and resume the normal dosing schedule. If a patient misses a dose of rilpivirine by more than 12 hours, the patient should not take the missed dose, but resume the usual dosing schedule.
If a patient vomits within 4 hours of taking the medicine, another rilpivirine dose should be taken with a meal. If a patient vomits more than 4 hours after taking the medicine, the patient does not need to take another dose of rilpivirine until the next regularly scheduled dose.
There is limited information regarding the use of rilpivirine in patients >65 years of age. No dose adjustment of rilpivirine is required in older patients. Rilpivirine should be used with caution in this population.
Rilpivirine must be taken with a meal.
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