Active Ingredient: Duloxetine
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 60 milligrams duloxetine, once daily, over the duration of 2 to 4 weeks. Afterwards, oral, between 60 milligrams duloxetine and 120 milligrams duloxetine, once daily.
The starting and recommended maintenance dose is 60 mg once daily with or without food. Dosages above 60 mg once daily, up to a maximum dose of 120 mg per day have been evaluated from a safety perspective in clinical trials. However, there is no clinical evidence suggesting that patients not responding to the initial recommended dose may benefit from dose up-titrations.
Therapeutic response is usually seen after 2-4 weeks of treatment.
After consolidation of the antidepressive response, it is recommended to continue treatment for several months, in order to avoid relapse. In patients responding to duloxetine, and with a history of repeated episodes of major depression, further long-term treatment at a dose of 60 to 120 mg/day could be considered.
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