Active Ingredient: Sebelipase alfa
Sebelipase alfa is indicated for long-term enzyme replacement therapy (ERT) in patients of all ages with lysosomal acid lipase (LAL) deficiency.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
1 - 1 mg per kg of body weight
From 1 To 1 mg per kg of body weight once every 14 day(s)
The recommended dose in children and adults who do not present with rapidly progressive LAL deficiency prior to 6 months of age is 1 mg/kg administered as an intravenous infusion once every other week.
The total volume of the infusion should be administered over approximately 2 hours. A 1-hour infusion may be considered after patient tolerability is established. The infusion period may be extended in the event of dose escalation.
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