Major depressive disorder

Active Ingredient: Gepirone

Indication for Gepirone

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

18.2 mg once daily on Days 1-3, 36.3 mg once daily on Day 4, 54.5 mg once daily after Day 7 and 72.6 mg once daily after an additional week

For:

Dosage regimens

Oral, 18.2 milligrams gepirone, once every minute, over the duration of 3 days. Afterwards, oral, 36.3 milligrams gepirone, once every minute, over the duration of 3 days. Afterwards, oral, 54.5 milligrams gepirone, once every minute, over the duration of 7 days. Afterwards, oral, 72.6 milligrams gepirone, once every minute.

Detailed description

The recommended starting dosage of gepirone is 18.2 mg once daily. Based on clinical response and tolerability, the dosage may be increased to 36.3 mg orally once daily on Day 4 and further titrated to 54.5 mg orally once daily after Day 7 and to 72.6 mg orally once daily after an additional week. The maximum recommended daily dosage is 72.6 mg once daily.

Dosage considerations

Take gepirone orally with food at approximately the same time each day.

18.2 mg once daily for 7 days and thereafter 18.2-36.3 mg once daily

For:

Dosage regimens

Oral, 18.2 milligrams gepirone, once daily, over the duration of 7 days. Afterwards, oral, between 18.2 milligrams gepirone and 36.3 milligrams gepirone, once daily. The maximum allowed total dose is 36.3 milligrams gepirone daily.

Detailed description

The recommended starting dosage of gepirone in geriatric patients is 18.2 mg orally once daily. Based on clinical response and tolerability, the dosage may be increased to maximum recommended dosage of 36.3 mg orally once daily after Day 7.

Dosage considerations

Take gepirone orally with food at approximately the same time each day.

Active ingredient

Gepirone

The mechanism of the antidepressant effect of gepirone is not fully understood but is thought to be related to its modulation of serotonergic activity in the CNS through selective agonist activity at 5HT1A receptors. The pharmacological activity of gepirone is attributed to the parent drug and its major metabolites 3'-OH-gepirone and 1-PP. Gepirone and its 3'-OH metabolite bind to 5HT1A receptors (Ki = 38 nM and 58 nM, respectively), where they act as agonists, while the 1-PP metabolite binds to alpha2 receptors (Ki = 42 nM).

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