Active Ingredient: Atezolizumab
Tecentriq as monotherapy is indicated as adjuvant treatment following complete resection and platinum-based chemotherapy for adult patients with NSCLC with a high risk of recurrence whose tumours have PD-L1 expression on ≥50% of tumour cells (TC) and who do not have EGFR mutant or ALK-positive NSCLC.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, 840 milligrams atezolizumab, once every 2 weeks, over the duration of 1 year.
Regimen B: Intravenous, 1,200 milligrams atezolizumab, once every 3 weeks, over the duration of 1 year.
Regimen C: Intravenous, 1,680 milligrams atezolizumab, once every 4 weeks, over the duration of 1 year.
The recommended dose of atezolizumab is either 840 mg administered intravenously every two weeks, or 1 200 mg administered intravenously every three weeks, or 1 680 mg administered intravenously every four weeks.
For 1 year unless disease recurrence or unacceptable toxicity. Treatment duration for more than 1 year was not studied.
If a planned dose of atezolizumab is missed, it should be administered as soon as possible. The schedule of administration must be adjusted to maintain the appropriate interval between doses.
Dose reductions of atezolizumab are not recommended.
The infusions must not be administered as an intravenous push or bolus.
The initial dose of atezolizumab must be administered over 60 minutes. If the first infusion is well tolerated, all subsequent infusions may be administered over 30 minutes.
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