Bronchospasm, chronic obstructive pulmonary disease (COPD), asthma, bronchitis

Active Ingredient: Ipratropium

Indication for Ipratropium

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Ipratropium is indicated for treatment of reversible bronchospasm associated with chronic obstructive pulmonary disease (COPD).

Ipratropium is indicated, when used concomitantly with inhaled beta2-agonists, for treatment of reversible airways obstruction as in acute and chronic asthma.

For this indication, competent medicine agencies globally authorize below treatments:

250-500 micrograms 3 to 4 times daily

Route of admnistration

Respiratory (Inhalation)

Defined daily dose

750 - 2,000 ug

Dosage regimen

From 187.5 To 500 ug 4 time(s) per day every day

Detailed description

250-500 micrograms (i.e. one vial of 250 micrograms in 1 ml or 1 vial of 500 micrograms in 2 ml) 3 to 4 times daily.

For treatment of acute bronchospasm, 500 micrograms.

Repeated doses can be administered until the patient is stable. The time interval between the doses may be determined by the physician.

It is advisable not to exceed the recommended daily dose during either acute or maintenance treatment. Daily doses exceeding 2 mg in adults and adolescents >12 years of age should only be given under medical supervision.

Active ingredient

Ipratropium

Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol).

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