Active Ingredient: Zinc sulfate
Zinc sulfate injection is indicated as a source of zinc for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 125 milligrams zinc sulfate, 1 to 3 times daily.
After meals.
For:
Regimen A: In case that patient weight is ≥ 30 kg, oral, 45 milligrams zinc sulfate, 1 to 3 times daily.
Regimen B: In case that patient weight is ≥ 10 kg and patient weight is ≤ 30 kg, oral, 22.5 milligrams zinc sulfate, 1 to 3 times daily.
Regimen C: In case that patient weight is ≤ 10 kg, oral, 22.5 milligrams zinc sulfate, once daily.
More than 30kg: 45 mg once to three times daily after meals.
10-30kg: 22.5 mg once to three times daily after meals.
Less than 10kg: 22.5 mg once daily after meals.
For:
Intravenous, 3 milligrams zinc sulfate, daily, one dose.
The recommended adult dosage is 3 mg/day for metabolically stable patients, with potential need for a higher daily dosage in monitored patients with small bowel fluid loss or excess stool or ileostomy output.
Monitor zinc concentrations during treatment. Also monitor patients clinically for signs and symptoms of zinc deficiency. Zinc concentrations may vary depending on the assay used and the laboratory reference range. The collection, processing, and storage of the blood samples for zinc analysis should be performed according to the laboratory’s sample requirements. Zinc concentrations in hemolyzed samples are falsely elevated due to release of zinc from erythrocytes. The lower end of the reported range in healthy adults in serum is 60 mcg/dL.
The final parenteral nutrition solution is for intravenous infusion into a central or peripheral vein. The choice of a central or peripheral venous route should depend on the osmolarity of the final infusate. Solutions with osmolarity of 900 mOsmol/L or greater must be infused through a central catheter.
For:
Regimen A: In case that patient weight is ≥ 10 kg, intravenous, 50 micrograms zinc sulfate per kilogram of body weight, daily, one dose.
Regimen B: In case that patient weight is ≥ 5 kg and patient weight is ≤ 10 kg, intravenous, 100 micrograms zinc sulfate per kilogram of body weight, daily, one dose.
The recommended pediatric dosage is shown in the table below by age and estimated weight. The dosages in the table are general recommendations intended for most pediatric patients. However, based on clinical requirements, some patients may require a higher dosage.
Recommended Dosage of Zinc Sulfate Injection for Pediatric Patients by Age and Estimated Weight:
| Population | Estimated Weight for Age | Recommended Daily Dosage |
|---|---|---|
| Pediatric patients | 10 kg and above | 50 mcg/kg (up to 3 mg/day) |
| 5 kg to less than 10 kg | 100 mcg/kg |
The final parenteral nutrition solution is for intravenous infusion into a central or peripheral vein. The choice of a central or peripheral venous route should depend on the osmolarity of the final infusate. Solutions with osmolarity of 900 mOsmol/L or greater must be infused through a central catheter.
For:
Regimen A: In case that patient weight is ≥ 3 kg and patient weight is ≤ 5 kg, intravenous, 250 micrograms zinc sulfate per kilogram of body weight, daily, one dose.
Regimen B: In case that patient weight is ≤ 3 kg, intravenous, 400 micrograms zinc sulfate per kilogram of body weight, daily, one dose.
The recommended pediatric dosage is shown in the table below by age and estimated weight. The dosages in the table are general recommendations intended for most pediatric patients. However, based on clinical requirements, some patients may require a higher dosage.
Recommended Dosage of Zinc Sulfate Injection for Pediatric Patients by Age and Estimated Weight:
| Population | Estimated Weight for Age | Recommended Daily Dosage |
|---|---|---|
| Term neonates | 3 kg to less than 5 kg | 250 mcg/kg* |
| Preterm neonates | Less than 3 kg | 400 mcg/kg |
* Term neonates have higher requirements in the first 3 months of life.
The final parenteral nutrition solution is for intravenous infusion into a central or peripheral vein. The choice of a central or peripheral venous route should depend on the osmolarity of the final infusate. Solutions with osmolarity of 900 mOsmol/L or greater must be infused through a central catheter.
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