Ototic scabies

Active Ingredient: Afoxolaner

Indication for Afoxolaner

For this indication, competent medicine agencies globally authorize below treatments:

2.7-7.0 mg/kg monthly

Dosage regimens

Oral, between 2.7 milligrams afoxolaner per kilogram of body weight and 7 milligrams afoxolaner per kilogram of body weight, once monthly.

Detailed description

The product should be administered at a dose of 2.7-6.9 mg/kg bodyweight in accordance with the following table:

Bodyweight of dog (kg) Strength and number of chewable tablets to be administered
afoxolaner 11 mg afoxolaner 28 mg afoxolaner 68 mg afoxolaner 136 mg
2–4 1   
>4–10  1  
>10–25  1 
>25–50   1

For dogs above 50 kg bodyweight, use an appropriate combination of chewable tablets of different/same strengths. The tablets should not be divided.

Dosage considerations

The tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly they may be administered with food.

Active ingredient

Afoxolaner

Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family. Afoxolaner acts at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. The selective toxicity of afoxolaner between insect/acarines and mammals may be inferred by the differential sensitivity of the insect/acarinesโ€™ GABA receptors versus mammalian receptors. Afoxolaner is active against adult fleas as well as several tick species such as Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Rhipicephalus sanguineus, Amblyomma americanum and Haemaphysalis longicornis.

Read more about Afoxolaner

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.