Active Ingredient: Aprepitant
Prevention nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in adolescents from the age of 12.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
80 - 125 mg
From 80 To 125 mg once every day
125 mg
80 mg
Aprepitant is given for 3 days as part of a regimen that includes a 5-HT3 antagonist. The recommended dose of capsules of aprepitant is 125 mg orally on Day 1 and 80 mg orally on Days 2 and 3. Aprepitant is administered orally 1 hour prior to chemotherapy on Days 1, 2 and 3. If no chemotherapy is given on Days 2 and 3, aprepitant should be administered in the morning. If a corticosteroid, such as dexamethasone, is co-administered with aprepitant, the dose of the corticosteroid should be administered at 50% of the usual dose.
The safety and efficacy of the 80 mg and 125 mg capsules have not been demonstrated in children less than 12 years of age. No data are available. Refer to the powder for oral suspension SmPC for appropriate dosing in infants, toddlers and children aged 6 months to less than 12 years.
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