Active Ingredient: Somatropin
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous
25 - 35 ug per kg of body weight
From 25 To 35 ug per kg of body weight once every day
Generally a dose of 0.7-1.0 mg/m² body surface area per day is recommended. Even higher doses have been used.
Where childhood onset GHD persists into adolescence, treatment should be continued to achieve full somatic development (e.g. body composition, bone mass). For monitoring, the attainment of a normal peak bone mass defined as a T score > - 1 (i.e. standardized to average adult peak bone mass measured by dual energy X-ray absorptiometry taking into account sex and ethnicity) is one of the therapeutic objectives during the transition period. For guidance on dosing see adult section below.
The injection should be given subcutaneously and the site varied to prevent lipoatrophy.
For:
Subcutaneous
0.7 - 1 mg per m² of body surface area (BSA)
From 0.7 To 1 mg per m² of body surface area (BSA) once every day
Generally a dose of 0.7-1.0 mg/m² body surface area per day is recommended. Even higher doses have been used.
Where childhood onset GHD persists into adolescence, treatment should be continued to achieve full somatic development (e.g. body composition, bone mass). For monitoring, the attainment of a normal peak bone mass defined as a T score > - 1 (i.e. standardized to average adult peak bone mass measured by dual energy X-ray absorptiometry taking into account sex and ethnicity) is one of the therapeutic objectives during the transition period. For guidance on dosing see adult section below.
The injection should be given subcutaneously and the site varied to prevent lipoatrophy.
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