Active Ingredient: Terlipressin
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous
4 - 12 mg
From 1 To 3 mg 4 time(s) per day every day for 7 day(s)
Treatment in adults is usually started with a dose of 1 mg terlipressin acetate# (5 ml of solution) at 4 to 6-hour intervals. The dose can be increased to a maximum of 2 mg terlipressin acetate# (10 ml of solution) every 4 hours if the serum creatinine does not decrease by at least 25% after 3 days of treatment.
# 1 mg terlipressin acetate corresponding to 0.85 mg terlipressin; 2 mg terlipressin acetate corresponding to 1.7 mg terlipressin
The treatment is continued until the serum creatinine has dropped below 1.5 mg/dl (133 µmol/l). In patients with a partial response (serum creatinine does not drop below 133 µmol/l) or in patients whose serum creatinine does not decrease, treatment should be stopped within 14 days.
In most clinical studies supporting the use of terlipressin for the treatment of hepatorenal syndrome, human albumin was administered simultaneously at a dosage of 1 g/kg of body weight on the first day and afterwards at a dosage of 20-40 g/day.
The usual duration of treatment of hepatorenal syndrome is 7 days, and the maximum recommended duration is 14 days.
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