Active Ingredient: Ocrelizumab
Ocrevus is indicated for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS) with active disease defined by clinical or imaging features.
Ocrevus is indicated for the treatment of adult patients with early primary progressive multiple sclerosis (PPMS) in terms of disease duration and level of disability, and with imaging features characteristic of inflammatory activity.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
300 - 600 mg
From 300 To 600 mg once every 14 day(s)
300 mg
600 mg
The following two premedications must be administered prior to each ocrelizumab infusion to reduce the frequency and severity of IRRs:
In addition, premedication with an antipyretic (e.g paracetamol) may also be considered approximately 30-60 minutes prior to each ocrelizumab infusion.
Initial Dose: The initial 600 mg dose is administered as two separate intravenous infusions; first as a 300 mg infusion, followed 2 weeks later by a second 300 mg infusion.
Subsequent Doses: Subsequent doses of ocrelizumab thereafter are administered as a single 600 mg intravenous infusion every 6 months. The first subsequent dose of 600 mg should be administered six months after the first infusion of the initial dose. A minimum interval of 5 months should be maintained between each dose of ocrelizumab.
After dilution, ocrelizumab is administered as an intravenous infusion through a dedicated line. Ocrelizumab infusions should not be administered as an intravenous push or bolus.
Dose and Schedule of ocrelizumab:
| Amount of ocrelizumab to be administered | Infusion instructions | ||
|---|---|---|---|
| Initial Dose (600 mg) divided into 2 infusions | Infusion 1 | 300 mg in 250 mL | Initiate the infusion at a rate of 30 mL/hour for 30 minutes |
| Infusion 2 (2 weeks later) | 300 mg in 250 mL | The rate can be increased in 30 mL/hour increments every 30 minutes to a maximum of 180 mL/hour. | |
| Each infusion should be given over approximately 2.5 hours. | |||
| Subsequent Doses (600 mg) once every 6 months | Single infusion | 600 mg in 500 mL | Initiate the infusion at a rate of 40 mL/hour for 30 minutes |
| The rate can be increased in 40 mL/hour increments every 30 minutes to a maximum of 200 mL/hour | |||
| Each infusion should be given over approximately 3.5 hours | |||
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