Thiamine deficiency, Wernicke-Korsakoff syndrome, beriberi, chronic alcoholism

Active Ingredient: Vitamin B1

Indication for Vitamin B1

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For the treatment of thiamine deficiencies due to increased dietary requirements, reduced intakes, reduced absorption or increased excretion. Also for treatment of Wernicke-Korsakoff syndrome, beriberi and thiamine deficiency related to chronic alcoholism.

Situations often accompanied by marginal thiamine deficiency and requiring supplementation include but are not limited to:

  • Regular heavy drinking/chronic alcohol consumption
  • High carbohydrate intakes
  • Heavy physical exertion
  • Compromised nutritional status
  • High dose diuretics
  • Type I and Type II diabetes mellitus

For this indication, competent medicine agencies globally authorize below treatments:

50-300 mg per day in 3 divided doses

Route of admnistration

Oral

Defined daily dose

50 - 300 mg

Dosage regimen

From 16.667 To 100 mg 3 time(s) per day every day

Detailed description

Adults and adolescents from 12 years of age:

Mild deficiency: 50-100mg per day.

Severe deficiency: 200-300mg per day in divided doses.

Not recommended for children under 12 years.

Active ingredient

Vitamin B1

Thiamine pyrophosphate (TPP), the coenzymatic form of thiamine, is involved in two main types of metabolic reactions: decarboxylation of α-ketoacids (e.g. pyruvate, α-ketoglutarate and branched-chain keto acids) and transketolation (e.g. among hexose and pentose phosphates). Therefore, the principal physiological role of thiamine is as a coenzyme in carbohydrate metabolism, where TPP is required for several stages in the breakdown of glucose to provide energy.

Read more about Vitamin B1

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