Major depressive episodes

Active Ingredient: Vortioxetine

Indication for Vortioxetine

Population group: only elderly (65 years old or older)

Vortioxetine is indicated for the treatment of major depressive episodes in adults.

For this indication, competent medicine agencies globally authorize below treatments:

5-10 mg once daily

Route of admnistration

Oral

Defined daily dose

5 - 10 mg

Dosage regimen

From 5 To 10 mg once every day

Loading dose

5 mg

Detailed description

The lowest effective dose of 5 mg vortioxetine once daily should always be used as the starting dose in patients ≥65 years of age. Caution is advised when treating patients ≥65 years of age with doses higher than 10 mg vortioxetine once daily for which data are limited.

After the depressive symptoms resolve, treatment for at least 6 months is recommended for consolidation of the antidepressive response.

Treatment discontinuation: Patients treated with vortioxetine can abruptly stop taking the medicinal product without the need for a gradual reduction in dose.

Active ingredient

Vortioxetine

Vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter, leading to modulation of neurotransmission in several systems, including predominantly the serotonin but probably also the norepinephrine, dopamine, histamine, acetylcholine, GABA and glutamate systems. This multimodal activity is considered responsible for the antidepressant and anxiolytic-like effects and the improvement of cognitive function, learning and memory observed with vortioxetine in animal studies.

Read more about Vortioxetine

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