Wilson's disease

Active Ingredient: Trientine

Indication for Trientine

Population group: only children (1 year - 12 years old)

Trientine is indicated for the treatment of Wilson’s disease in adults, adolescents and children ≥5 years intolerant to D-penicillamine therapy.

For this indication, competent medicine agencies globally authorize below treatments:

225-600 mg in 2-4 divided doses daily

Route of admnistration

Oral

Defined daily dose

225 - 600 mg

Dosage regimen

From 56.25 To 150 mg 4 time(s) per day every day

Detailed description

The starting dose in paediatrics is lower than for adults and depends on age and body weight.

Children ≥5 years

The dose is usually between 225 mg and 600 mg per day in 2 to 4 divided doses.

Children aged <5 years

The safety and efficacy of trientine in children aged <5 years have not been established. The pharmaceutical form is not suitable for administration to children <5 years.

Dosage considerations

It is important that trientine is given on an empty stomach, at least one hour before meals or two hours after meals and at least one hour apart from any other medicinal product, food, or milk.

Active ingredient

Trientine

Trientine is a copper-chelating agent whose principal mechanism of action is to eliminate absorbed copper from the body by forming a stable complex that is then eliminated through urinary excretion. Trientine may also chelate copper in the intestinal tract and so inhibit copper absorption.

Read more about Trientine

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