Active Ingredient: 4-Aminosalicylic acid
4-Aminosalicylic acid is indicated for use as part of an appropriate combination regimen for multi-drug resistant tuberculosis in adults and paediatric patients from 28 days of age and older when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability.
Consideration should be given to official guidance on the appropriate use of antibacterial agents.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
12 g
4 g 3 time(s) per day every day for 730 day(s)
4 g three times per day. The recommended schedule is 4 g every 8 hours.
Maximum daily dose is 12 g. Usual duration of treatment is 24 months.
Desensitization can be accomplished by starting with 10 mg para-aminosalicylic acid (PAS) given as a single dose. The dosage is doubled every 2 days until reaching a total of 1 gram after which the dosage is divided to follow the regular schedule of administration. If a mild temperature rise or skin reaction develops, the increment is to be dropped back one level or the progression held for one cycle. Reactions are rare after a total dosage of 1.5 g.
4-Aminosalicylic acid can be taken with food.
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