Active Ingredient: Carbamazepine
Carbamazepine is indicated for generalised tonic-clonic and partial seizures.
Carbamazepine is not usually effective in absences (petit mal) and myoclonic seizures. Moreover, anecdotal evidence suggests that seizure exacerbation may occur in patients with atypical absences.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
100 - 2,000 mg
From 50 To 1,000 mg 2 time(s) per day every day
100 mg
The dose of carbamazepine should be adjusted to the needs of the individual patient to achieve adequate control of seizures. Determination of plasma levels may help in establishing the optimum dosage. In the treatment of epilepsy, the dose of carbamazepine usually requires total plasma-carbamazepine concentrations of about 4 to 12 micrograms/ml (17 to 50 micromoles/litre) (see warnings and precautions).
It is advised that with all formulations of carbamazepine, a gradually increasing dosage scheme is used and this should be adjusted to suit the needs of the individual patient.
Carbamazepine should be taken in a number of divided doses although initially 100-200 mg once to twice daily is recommended. This may be followed by a slow increase until the best response is obtained, often 800-1200 mg daily. In some instances, 1600 mg or even 2000 mg daily may be necessary.
Due to the potential for drug interactions, the dosage of carbamazepine should be selected with caution in elderly patients.
It may be taken during, after or between meals.
Rectal
100 - 1,000 mg
From 25 To 250 mg 4 time(s) per day every day
100 mg
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