Heterozygous familial hypercholesterolaemia

Active Ingredient: Atorvastatin

Indication for Atorvastatin

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

10 mg once daily for 4 weeks and thereafter 10-80 mg once daily

For:

Dosage regimens

Oral, 10 milligrams atorvastatin, once daily, over the duration of 4 weeks. Afterwards, oral, between 10 milligrams atorvastatin and 80 milligrams atorvastatin, once daily. The maximum allowed total dose is 80 milligrams atorvastatin daily.

Detailed description

Patients should be started with atorvastatin 10 mg daily. Doses should be individualised and adjusted every 4 weeks to 40 mg daily. Thereafter, either the dose may be increased to a maximum of 80 mg daily or a bile acid sequestrant may be combined with 40 mg atorvastatin once daily.

Dosage considerations

Each daily dose of atorvastatin is given all at once and may be given at any time of day with or without food.

10 mg once daily for 4 weeks and thereafter 10-20 mg once daily

For:

Dosage regimens

In case that patient age in years is ≥ 10, oral, 10 milligrams atorvastatin, once daily, over the duration of 4 weeks. Afterwards, in case that patient age in years is ≥ 10, oral, between 10 milligrams atorvastatin and 20 milligrams atorvastatin, once daily.

Detailed description

The recommended starting dosage of atorvastatin is 10 mg once daily. The dosage range is 10 mg to 20 mg once daily.

Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating atorvastatin, and adjust the dosage if necessary.

Dosage considerations

Take atorvastatin orally once daily at any time of the day, with or without food.

Active ingredient

Atorvastatin

Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase. Atorvastatin lowers plasma cholesterol and lipoprotein serum concentrations by inhibiting HMG-CoA reductase and subsequently cholesterol biosynthesis in the liver and increases the number of hepatic LDL receptors on the cell surface for enhanced uptake and catabolism of LDL.

Read more about Atorvastatin

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