Active Ingredient: Bupropion
Bupropion is indicated as an aid to smoking cessation in combination with motivational support in nicotine-dependent patients.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 150 milligrams bupropion, once daily, over the duration of 6 days. Afterwards, oral, 150 milligrams bupropion, 2 times daily, over the duration of 6 to 8 weeks. The maximum allowed total dose is 300 milligrams bupropion daily.
It is recommended that treatment is started while the patient is still smoking and a “target stop date” set within the first two weeks of treatment with bupropion, preferably in the second week. The initial dose is 150mg to be taken daily for six days, increasing on day seven to 150 mg twice daily.
There should be an interval of at least 8 hours between successive doses.
The maximum single dose must not exceed 150 mg and the maximum total daily dose must not exceed 300 mg.
Insomnia is a very common adverse event which can be reduced by avoiding bedtime doses of bupropion (provided there is at least 8 hours between doses).
Patients should be treated for 7-9 weeks. If at seven weeks no effect is seen, treatment should be discontinued.
Although discontinuation reactions are not expected with bupropion, a tapering-off period may be considered.
It can be taken with or without food.
For:
Oral, 150 milligrams bupropion, once daily, over the duration of 7 to 9 weeks.
Bupropion should be used with caution in older people. Greater sensitivity in some older individuals cannot be ruled out. The recommended dose in older people is 150 mg once a day.
Patients should be treated for 7-9 weeks. If at seven weeks no effect is seen, treatment should be discontinued.
Although discontinuation reactions are not expected with bupropion, a tapering-off period may be considered.
It can be taken with or without food.
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