Severe hypertriglyceridemia

Active Ingredient: Eicosapentaenoic acid

Indication for Eicosapentaenoic acid

Population group: only adults (18 years old or older)

Therapeutic intent: Adjunct intent

Eicosapentaenoic acid is indicated as an adjunct to diet to reduce TG levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia.

For this indication, competent medicine agencies globally authorize below treatments:

2 g twice daily

For:

Dosage regimens

Oral, 2 grams eicosapentaenoic acid, 2 times daily.

Detailed description

The daily dose is 4 grams per day taken as either 2 grams twice daily with food.

Active ingredient

Eicosapentaenoic acid
Icosapent ethyl is a stable ethyl ester of the omega-3 fatty acid, eicosapentaenoic acid (EPA). The mechanisms of action contributing to reduction of cardiovascular events with icosapent ethyl are not completely understood. The mechanisms are likely multi-factorial including improved lipoprotein profile with reduction of triglyceride-rich lipoproteins, anti-inflammatory, and antioxidant effects, reduction of macrophage accumulation, improved endothelial function, increased fibrous cap thickness/stability, and antiplatelet effects. Each of these mechanisms can beneficially alter the development, progression, and stabilisation of atherosclerotic plaque, as well as the implications of plaque rupture, and preclinical and clinical studies support such benefits with EPA. Read more about Eicosapentaenoic acid

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