Active Ingredient: Nogapendekin alfa
Nogapendekin alfa inbakicept-pmln in combination with Bacillus Calmette-Guérin (BCG) is indicated for the treatment of adult patients with BCG-unresponsive nonmuscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravesical, 400 micrograms nogapendekin alfa, once weekly, 6 doses in total, over the duration of 3 months. Afterwards, intravesical, 400 micrograms nogapendekin alfa, once weekly, 3 doses in total, over the duration of 3 months. Afterwards, intravesical, 400 micrograms nogapendekin alfa, once weekly, 3 doses in total, over the duration of 3 months. Afterwards, intravesical, 400 micrograms nogapendekin alfa, once weekly, 3 doses in total, over the duration of 3 months. Afterwards, intravesical, 400 micrograms nogapendekin alfa, once weekly, 3 doses in total, over the duration of 6 months. Afterwards, intravesical, 400 micrograms nogapendekin alfa, once weekly, 3 doses in total, over the duration of 6 months. Afterwards, in case that there is very good treatment response, intravesical, 400 micrograms nogapendekin alfa, once weekly, 3 doses in total, over the duration of 6 months. This step is repeated 3 times.
For induction: nogapendekin alfa inbakicept is recommended at a dose of 400 mcg administered intravesically with BCG once a week for 6 weeks. A second induction course may be administered if complete response is not achieved at month 3.
For maintenance: After BCG and nogapendekin alfa inbakicept induction therapy, nogapendekin alfa inbakicept is recommended at a dose of 400 mcg administered intravesically with BCG once a week for 3 weeks at months 4, 7, 10, 13 and 19 (for a total of 15 doses). For patients with an ongoing complete response at month 25 and later, maintenance instillations with BCG may be administered once a week for 3 weeks at months 25, 31, and 37 for a maximum of 9 additional instillations.
The recommended duration of treatment is until disease persistence after second induction, disease recurrence or progression, unacceptable toxicity, or a maximum of 37 months.
For intravesical use only. Do NOT administer by subcutaneous or intravenous or intramuscular routes.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.