Invasive candidiasis

Active Ingredient: Micafungin

Indication for Micafungin

Population group: only children (1 year - 12 years old)

Treatment of invasive candidiasis.

For this indication, competent medicine agencies globally authorize below treatments:

2 mg/kg once daily

Route of admnistration

Intravenous

Defined daily dose

2 - 2 mg per kg of body weight

Dosage regimen

From 2 To 2 mg per kg of body weight once every day

Detailed description

Use in children ≥4 months of age up to adolescents <16 years of age:

IndicationBody weight >40 kgBody weight ≤40 kg
Treatment of invasive candidiasis100 mg/day*2 mg/kg/day*

* If the patient’s response is inadequate, e.g. persistence of cultures or if clinical condition does not improve, the dose may be increased to 200 mg/day in patients weighing >40 kg or 4 mg/kg/day in patients weighing ≤40 kg.

Treatment duration

Invasive candidiasis: The treatment duration of Candida infection should be a minimum of 14 days. The antifungal treatment should continue for at least one week after two sequential negative blood cultures have been obtained and after resolution of clinical signs and symptoms of infection.

Dosage considerations

After reconstitution and dilution, the solution should be administered by intravenous infusion over approximately 1 hour.

Active ingredient

Micafungin

Micafungin non-competitively inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall. 1,3-β-D-glucan is not present in mammalian cells. Micafungin exhibits fungicidal activity against most Candida species and prominently inhibits actively growing hyphae of Aspergillus species.

Read more about Micafungin

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