Active Ingredient: Naloxone
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 0.01 milligrams naloxone per kilogram of body weight, one dose. Afterwards, intravenous, 0.1 milligrams naloxone per kilogram of body weight, one dose.
The usual starting dose is 0.01 mg naloxone hydrochloride per kg i.v. If the satisfactory clinical response is not achieved, the dose can be increased in the next injection to 0.1 mg/kg. Depending on the individual patient, an i.v. infusion may also be necessary.
For:
Intramuscular, 0.01 milligrams naloxone per kilogram of body weight, one dose. Afterwards, intramuscular, 0.01 milligrams naloxone per kilogram of body weight, one dose.
The usual starting dose is 0.01 mg naloxone hydrochloride per kg i.v. If the satisfactory clinical response is not achieved, the dose can be increased in the next injection to 0.1 mg/kg. Depending on the individual patient, an i.v. infusion may also be necessary. If i.v. administration is not possible, naloxone can also be injected i.m. (initial dose 0.01 mg/kg), divided into several doses.
For:
Intravenous, between 0.4 milligrams naloxone and 2 milligrams naloxone, once every 2 to 3 minutes.
The initial dose is usually 0.4-2 mg naloxone hydrochloride i.v. If the desired improvement in the respiratory depression is not obtained immediately after i.v. administration, the injections can be repeated at intervals of 2-3 minutes.
If 10 mg naloxone hydrochloride does not produce a significant improvement, this suggests that the depression is wholly or partially caused by other pathological conditions or active substances other than opioids.
For:
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The initial dose is usually 0.4-2 mg naloxone hydrochloride i.v. If the desired improvement in the respiratory depression is not obtained immediately after i.v. administration, the injections can be repeated at intervals of 2-3 minutes.
Naloxone can also be injected intramuscularly (initial dose usually 0.4-2 mg) if intravenous administration is not possible.
If 10 mg naloxone hydrochloride does not produce a significant improvement, this suggests that the depression is wholly or partially caused by other pathological conditions or active substances other than opioids.
For:
Regimen A: Intrasinal, 2 milligrams naloxone, once every 2 to 3 minutes.
Regimen B: Intrasinal, 4 milligrams naloxone, once every 2 to 3 minutes.
Naloxone nasal spray is indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression.
It is intended for immediate administration as emergency therapy in settings where opioids may be present.
It is not a substitute for emergency medical care.
The recommended initial dose in adults and pediatric patients is one spray delivered by intranasal administration into one nostril.
Seek emergency medical assistance as soon as possible after administering the first dose of naloxone nasal spray.
The requirement for repeat doses of naloxone nasal spray depends upon the amount, type, and route of administration of the opioid being antagonized.
Administer naloxone nasal spray in alternate nostrils with each dose.
If the patient responds to naloxone nasal spray and relapses back into respiratory depression before emergency assistance arrives, administer an additional dose of naloxone nasal spray and continue surveillance of the patient.
If the desired response is not obtained after 2 or 3 minutes, administer an additional dose of naloxone nasal spray. If there is still no response and additional doses are available, administer additional doses of naloxone nasal spray every 2 to 3 minutes until emergency medical assistance arrives.
Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.
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