Active Ingredient: Dupilumab
Dupilumab is indicated for the treatment of eosinophilic esophagitis in adults and adolescents 12 years and older, weighing at least 40 kg, who are inadequately controlled by, are intolerant to, or who are not candidates for conventional medicinal therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 300 milligrams dupilumab, once weekly.
The recommended dose of dupilumab for patients 12 years of age and older is 300 mg given every week (QW).
Dupilumab 300 mg QW has not been studied in patients with EoE weighing less than 40 kg.
Dupilumab is intended for long-term treatment. Dupilumab 300 mg QW has been studied up to 52 weeks. Dosing beyond 52 weeks has not been studied.
If a weekly dose is missed, administer the dose as soon as possible, starting a new schedule based on this date.
Dupilumab is administered by subcutaneous injection into the thigh or abdomen, except for the 5 cm around the navel. If somebody else administers the injection, the upper arm can also be used.
It is recommended to rotate the injection site with each injection. Dupilumab should not be injected into skin that is tender, damaged or has bruises or scars.
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