Active Ingredient: Voclosporin
Voclosporin is indicated in combination with mycophenolate mofetil for the treatment of adult patients with active class III, IV or V (including mixed class III/V and IV/V) lupus nephritis (LN).
For this indication, competent medicine agencies globally authorize below treatments:
For:
In case that patient age in years is ≤ 75, oral, 23.7 milligrams voclosporin, 2 times daily.
The recommended dose is 23.7 mg, twice daily.
It is recommended that voclosporin is administered consistently as close to a 12-hour schedule as possible and with a minimum of 8 hours between each dose. If a dose is missed, it should be taken as soon as possible within 4 hours after missing the dose; beyond the 4-hour time frame, the next regular dose should be taken at the usual scheduled time. The next dose should not be doubled.
Voclosporin should be used in combination with mycophenolate mofetil.
Physicians should evaluate the efficacy of treatment at a time point of at least 24 weeks and make an appropriate risk-benefit analysis for continuation of therapy.
Voclosporin must be taken with or without food.
It is recommended not to take Lupkynis with grapefruit or grapefruit juice.
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