Active Ingredient: Atezolizumab
Atezolizumab as monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma (UC):
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, 840 milligrams atezolizumab, once every 2 weeks.
Regimen B: Intravenous, 1,200 milligrams atezolizumab, once every 3 weeks.
Regimen C: Intravenous, 1,680 milligrams atezolizumab, once every 4 weeks.
The recommended dose of atezolizumab is either 840 mg administered intravenously every two weeks, or 1 200 mg administered intravenously every three weeks, or 1 680 mg administered intravenously every four weeks.
1L UC:
Until disease progression or unmanageable toxicity.
2L UC:
Until loss of clinical benefit or unmanageable toxicity.
If a planned dose of atezolizumab is missed, it should be administered as soon as possible. The schedule of administration must be adjusted to maintain the appropriate interval between doses.
Dose reductions of atezolizumab are not recommended.
The infusions must not be administered as an intravenous push or bolus.
The initial dose of atezolizumab must be administered over 60 minutes. If the first infusion is well tolerated, all subsequent infusions may be administered over 30 minutes.
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