Obsessive compulsive disorder (OCD)

Active Ingredient: Sertraline

Indication for Sertraline

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

50 mg once daily and thereafter 50-200 mg once daily

For:

Dosage regimens

Oral, 50 milligrams sertraline, once daily, over the duration of 1 week. Afterwards, oral, between 50 milligrams sertraline and 200 milligrams sertraline, once daily. The maximum allowed total dose is 200 milligrams sertraline daily.

Detailed description

Initial treatment

Sertraline treatment should be started at a dose of 50 mg/day.

Titration

Patients not responding to a 50 mg dose may benefit from dose increases. Dose changes should be made in steps of 50 mg at intervals of at least one week, up to a maximum of 200 mg/day. Changes in dose should not be made more frequently than once per week given the 24-hour elimination half life of sertraline.

The onset of therapeutic effect may be seen within 7 days. However, longer periods are usually necessary to demonstrate therapeutic response, especially in OCD.

Maintenance

Dosage during long-term therapy should be kept at the lowest effective level, with subsequent adjustment depending on therapeutic response.

Continued treatment in OCD should be evaluated regularly, as relapse prevention has not been shown for these disorders.

Dosage considerations

Sertraline should be administered once daily, either in the morning or evening.

Sertraline tablet can be administered with or without food.

50 mg once daily and thereafter 50-200 mg once daily

For:

Dosage regimens

Oral, 50 milligrams sertraline, once daily, over the duration of 1 week. Afterwards, oral, between 50 milligrams sertraline and 200 milligrams sertraline, once daily. The maximum allowed total dose is 200 milligrams sertraline daily.

Detailed description

Age 13-17 years

Initially 50 mg once daily.

Subsequent doses may be increased in case of less than desired response in 50 mg increments over a period of some weeks, as needed. The maximum dosage is 200 mg daily. However, the generally lower body weights of children compared to those of adults should be taken into consideration when increasing the dose from 50 mg. Dose changes should not occur at intervals of less than one week.

Dosage considerations

Sertraline should be administered once daily, either in the morning or evening.

Sertraline can be administered with or without food.

25 mg once daily and thereafter 50-200 mg once daily

For:

Dosage regimens

Oral, 25 milligrams sertraline, once daily, over the duration of 1 week. Afterwards, oral, between 50 milligrams sertraline and 200 milligrams sertraline, once daily. The maximum allowed total dose is 200 milligrams sertraline daily.

Detailed description

Age 6-12 years

Initially 25 mg once daily. The dosage may be increased to 50 mg once daily after one week.

Subsequent doses may be increased in case of less than desired response in 50 mg increments over a period of some weeks, as needed. The maximum dosage is 200 mg daily. However, the generally lower body weights of children compared to those of adults should be taken into consideration when increasing the dose from 50 mg. Dose changes should not occur at intervals of less than one week.

No data is available for children under 6 years of age.

Dosage considerations

Sertraline should be administered once daily, either in the morning or evening.

Sertraline can be administered with or without food.

Active ingredient

Sertraline

Sertraline is a potent and specific inhibitor of neuronal serotonin (5-HT) uptake in vitro, which results in the potentiation of the effects of 5-HT in animals. It has only very weak effects on norepinephrine and dopamine neuronal reuptake.

Read more about Sertraline

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