Asthma

Active Ingredient: Tiotropium

Indication for Tiotropium

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Tiotropium is indicated as add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma who experienced one or more severe asthma exacerbations in the preceding year.

For this indication, competent medicine agencies globally authorize below treatments:

5 ug once daily

For:

Dosage regimens

Respiratory (Inhalation), 5 micrograms tiotropium, once daily.

Detailed description

The recommended dose is 5 microgram tiotropium once daily, at the same time of the day.

The recommended dose should not be exceeded.

In the treatment of asthma the full benefit will be apparent after several doses of the medicinal product. In adult patients with severe asthma, tiotropium should be used in addition to inhaled corticosteroids (≥800 μg budesonide/day or equivalent) and at least one controller.

5 ug once daily

For:

Dosage regimens

Respiratory (Inhalation), 5 micrograms tiotropium, once daily.

Detailed description

The recommended dose for patients 6 to 17 years of age is 5 microgram tiotropium once daily, at the same time of the day.

In adolescents (12-17 years) with severe asthma, tiotropium should be used in addition to inhaled corticosteroids (>800-1600 µg budesonide/day or equivalent) and one controller or in addition to inhaled corticosteroids (400-800 µg budesonide/day or equivalent) with two controllers.

For children (6-11 years) with severe asthma, tiotropium should be used in addition to inhaled corticosteroids (>400 µg budesonide/day or equivalent) and one controller or in addition to inhaled corticosteroids (200-400 µg budesonide/day or equivalent) with two controllers.

The safety and efficacy of tiotropium in children aged 6-17 years with moderate asthma has not been established. The safety and efficacy of tiotropium in children below 6 years of age has not been established.

Active ingredient

Tiotropium

Tiotropium is a long-acting, specific, muscarinic receptor antagonist, in clinical medicine often called an anticholinergic. By binding to the muscarinic receptors in the bronchial smooth musculature, tiotropium inhibits the cholinergic (bronchoconstrictive) effects of acetylcholine, released from parasympathetic nerve endings.

Read more about Tiotropium

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