Friedreich's ataxia

Active Ingredient: Omaveloxolone

Indication for Omaveloxolone

Population group: only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

150 mg once daily

For:

Dosage regimens

In case that patient age in years is ≥ 16, oral, 150 milligrams omaveloxolone, once daily.

Detailed description

The recommended dose is 150 mg omaveloxolone once daily.

Medicine lost through emesis should not be replaced with an additional dose.

If a dose is missed, the next dose should be taken as usual the following day. A double dose should not be taken to make up for a missed dose.

Dosage considerations

Omaveloxolone should be taken on an empty stomach at least 1 hour before or 2 hours after eating.

Active ingredient

Omaveloxolone

The precise mechanism by which omaveloxolone exerts its therapeutic effect in patients with Friedreich’s ataxia is unknown. Omaveloxolone has been shown to activate the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway in vitro and in vivo in animals and humans. The Nrf2 pathway is involved in the cellular response to oxidative stress. There is substantial evidence that Nrf2 levels and activity are suppressed in cells from patients with Friedreich’s ataxia.

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