Type 2 diabetes mellitus, monotherapy

Active Ingredient: Dulaglutide

Indication for Dulaglutide

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Dulaglutide is indicated for the treatment of patients 10 years and above with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise as monotherapy when metformin is considered inappropriate due to intolerance or contraindications.

For this indication, competent medicine agencies globally authorize below treatments:

0.75 mg once weekly

For:

Dosage regimens

Subcutaneous, 0.75 milligrams dulaglutide, once weekly.

Detailed description

The recommended dose is 0.75 mg once weekly.

Missed doses

If a dose is missed, it should be administered as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If less than 3 days (72 hours) remain before the next scheduled dose, the missed dose should be skipped and the next dose should be administered on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.

Dosage considerations

Dulaglutide is to be injected subcutaneously in the abdomen, thigh or upper arm. It should not be administered intravenously or intramuscularly.

The dose can be administered at any time of day, with or without meals.

The day of weekly administration can be changed if necessary, as long as the last dose was administered 3 or more days (72 hours) before.

0.75-1.5 mg once weekly

For:

Dosage regimens

In case that patient age in years is ≥ 10, subcutaneous, between 0.75 milligrams dulaglutide and 1.5 milligrams dulaglutide, once weekly.

Detailed description

The starting dose for paediatric patients 10 years and above is 0.75 mg once weekly.

If needed, the dose can be increased to 1.5 mg once weekly after at least 4 weeks. The maximum dose is 1.5 mg once weekly.

Missed doses

If a dose is missed, it should be administered as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If less than 3 days (72 hours) remain before the next scheduled dose, the missed dose should be skipped and the next dose should be administered on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.

Dosage considerations

Dulaglutide is to be injected subcutaneously in the abdomen, thigh or upper arm. It should not be administered intravenously or intramuscularly.

The dose can be administered at any time of day, with or without meals.

The day of weekly administration can be changed if necessary, as long as the last dose was administered 3 or more days (72 hours) before.

Active ingredient

Dulaglutide

Dulaglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist. Dulaglutide exhibits several antihyperglycaemic actions of GLP-1. In the presence of elevated glucose concentrations, dulaglutide increases intracellular cyclic AMP (cAMP) in pancreatic beta cells leading to insulin release. Dulaglutide suppresses glucagon secretion which is known to be inappropriately elevated in patients with type 2 diabetes.

Read more about Dulaglutide

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