Transthyretin amyloidosis

Active Ingredient: Tafamidis

Indication for Tafamidis

Population group: only adults (18 - 65 years old)

Tafamidis is indicated for the treatment of transthyretin amyloidosis in adult patients with stage 1 symptomatic polyneuropathy to delay peripheral neurologic impairment.

For this indication, competent medicine agencies globally authorize below treatments:

20 mg once daily

Route of admnistration

Oral

Defined daily dose

20 - 20 mg

Dosage regimen

From 20 To 20 mg once every day

Detailed description

The recommended dose of tafamidis meglumine is 20 mg orally once daily.

Tafamidis and tafamidis meglumine are not interchangeable on a per mg basis.

If vomiting occurs after dosing, and the intact tafamidis capsule is identified, then an additional dose of tafamidis should be administered if possible. If no capsule is identified, then no additional dose is necessary, with resumption of dosing the next day as usual.

Dosage considerations

Tafamidis may be taken with or without food.

Active ingredient

Tafamidis

Tafamidis is a selective stabiliser of transthyretin (TTR). Tafamidis binds to TTR at the thyroxine binding sites, stabilising the tetramer and slowing dissociation into monomers, the rate-limiting step in the pathogenesis of transthyretin amyloidosis.

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