Irritable bowel syndrome with diarrhoea (IBS-D)

Active Ingredient: Eluxadoline

Indication for Eluxadoline

Population group: only adults (18 years old or older)

Eluxadoline is indicated in adults for the treatment of irritable bowel syndrome with diarrhoea (IBS-D).

For this indication, competent medicine agencies globally authorize below treatments:

150-200 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

150 - 200 mg

Dosage regimen

From 75 To 100 mg 2 time(s) per day every day

Detailed description

The treatment should be initiated and supervised by a physician experienced in diagnosis and management of gastrointestinal disorders.

The recommended dose is 200 mg daily (100 mg, twice daily).

For patients who are unable to tolerate the 200 mg daily dose (100 mg, twice daily), the dose can be lowered to 150 mg daily (75 mg twice daily).

Dosage considerations

It should be taken with food in the morning and in the evening.

Active ingredient

Eluxadoline

Eluxadoline is a locally acting, mixed mu opioid receptor (μOR) agonist and delta opioid receptor (δOR) antagonist. Eluxadoline is also an agonist at the kappa opioid receptor (κOR). Eluxadoline has demonstrated efficacy in normalizing GI transit and defecation in several models of stress induced or post GI inflammation-altered GI function in animals.

Read more about Eluxadoline

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