Psoriatic arthritis

Active Ingredient: Ixekizumab

Indication for Ixekizumab

Population group: only adults (18 years old or older)

Ixekizumab, alone or in combination with methotrexate, is indicated for the treatment of active psoriatic arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drug (DMARD) therapies.

For this indication, competent medicine agencies globally authorize below treatments:

80-160 mg once every 4 weeks

Route of admnistration

Subcutaneous

Defined daily dose

80 - 160 mg

Dosage regimen

From 80 To 160 mg once every 28 day(s)

Loading dose

160 mg

Maintenance dose

80 mg

Detailed description

The recommended dose is 160 mg by subcutaneous injection at Week 0, followed by 80 mg every 4 weeks thereafter. For psoriatic arthritis patients with concomitant moderate to severe plaque psoriasis, the recommended dosing regimen is the same as for plaque psoriasis.

Consideration should be given to discontinuing treatment in patients who have shown no response after 16 to 20 weeks of treatment. Some patients with initially partial response may subsequently improve with continued treatment beyond 20 weeks.

Dosage considerations

If possible, areas of the skin that show psoriasis should be avoided as injection sites.

Active ingredient

Ixekizumab

Ixekizumab is an IgG4 monoclonal antibody that binds with high affinity (<3 pM) and specificity to interleukin 17A (both IL-17A and IL-17A/F). Elevated concentrations of IL-17A have been implicated in the pathogenesis of psoriasis by promoting keratinocyte proliferation and activation, as well as in the pathogenesis of psoriatic arthritis. Neutralisation of IL-17A by ixekizumab inhibits these actions.

Read more about Ixekizumab

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