Active Ingredient: Nemolizumab
Nemolizumab is indicated for the treatment of adults with moderate-to-severe prurigo nodularis who are candidates for systemic therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: In case that patient weight is < 90 kg, subcutaneous, 60 milligrams nemolizumab, one dose. Afterwards, in case that patient weight is < 90 kg, subcutaneous, 30 milligrams nemolizumab, once every 4 weeks.
Regimen B: In case that patient weight is ≥ 90 kg, subcutaneous, 60 milligrams nemolizumab, one dose. Afterwards, in case that patient weight is ≥ 90 kg, subcutaneous, 60 milligrams nemolizumab, once every 4 weeks.
The recommended dose for patients weighing <90 kg is an initial dose of 60 mg, followed by 30 mg given every 4 weeks (Q4W).
The recommended dose for patients weighing ≥90 kg is an initial dose of 60 mg, followed by 60 mg given every 4 weeks (Q4W).
Consideration should be given to discontinuing treatment in patients who have shown no response on pruritus after 16 weeks of treatment for prurigo nodularis.
If a dose is missed, it should be administered as soon as possible. Thereafter, dosing should be resumed at the regular scheduled time.
The subcutaneous injection should be administered into the front upper thighs or abdomen avoiding the 5 cm area around the navel. Injection into the upper arm should only be performed by a caregiver or healthcare professional.
For subsequent doses, it is recommended to rotate the injection site with each dose. Nemolizumab should not be injected into skin that is tender, inflamed, swollen, damaged or has bruises, scars or open wounds.
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