Active Ingredient: Sertraline
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 25 milligrams sertraline, once daily, over the duration of 1 week. Afterwards, oral, between 50 milligrams sertraline and 200 milligrams sertraline, once daily. The maximum allowed total dose is 200 milligrams sertraline daily.
Therapy should be initiated at 25 mg/day. After one week, the dose should be increased to 50 mg once daily. This dosage regimen has been shown to reduce the frequency of early treatment emergent side effects characteristic of panic disorder.
Patients not responding to a 50 mg dose may benefit from dose increases. Dose changes should be made in steps of 50 mg at intervals of at least one week, up to a maximum of 200 mg/day. Changes in dose should not be made more frequently than once per week given the 24-hour elimination half life of sertraline.
The onset of therapeutic effect may be seen within 7 days. However, longer periods are usually necessary to demonstrate therapeutic response.
Dosage during long-term therapy should be kept at the lowest effective level, with subsequent adjustment depending on therapeutic response.
Continued treatment in panic disorder should be evaluated regularly, as relapse prevention has not been shown for these disorders.
Sertraline should be administered once daily, either in the morning or evening.
Sertraline can be administered with or without food.
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