Uveitis

Active Ingredient: Adalimumab

Indication for Adalimumab

Population group: only adults (18 years old or older)

Adalimumab is indicated for the treatment of non-infectious intermediate, posterior and panuveitis in adult patients who have had an inadequate response to corticosteroids, in patients in need of corticosteroidsparing, or in whom corticosteroid treatment is inappropriate.

For this indication, competent medicine agencies globally authorize below treatments:

Initial dose of 80 mg, followed by 40 mg given every other week

Route of admnistration

Subcutaneous

Defined daily dose

40 - 80 mg

Dosage regimen

From 40 To 80 mg once every 14 day(s)

Loading dose

80 mg

Maintenance dose

40 mg

Detailed description

The recommended dose of adalimumab for adult patients with uveitis is an initial dose of 80 mg, followed by 40 mg given every other week starting one week after the initial dose.

There is limited experience in the initiation of treatment with adalimumab alone. Treatment with adalimumab can be initiated in combination with corticosteroids and/or with other non-biologic immunomodulatory agents. Concomitant corticosteroids may be tapered in accordance with clinical practice starting two weeks after initiating treatment with adalimumab.

It is recommended that the benefit and risk of continued long-term treatment should be evaluated on a yearly basis.

Adalimumab may be available in other strengths and/or presentations depending on the individual treatment needs.

Active ingredient

Adalimumab

Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).

Read more about Adalimumab

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